Presentation Summary

In this presentation, the role of mechanical forces and extracellular matrix (ECM) components in regulating cellular functions crucial for tissue engineering is discussed. Topics include key mechanical players in the ECM, including collagen fibrils, elastic fibers, and proteoglycans, and how these elements influence cellular responses such as migration, proliferation, and differentiation. The significance of mechanotransduction is also explained, where cells convert mechanical signals into biochemical ones. we also explore the impact of substrate stiffness, viscoelasticity, and viscoplasticity on cell behavior. Additionally, advances in scaffold biomaterials, which are designed to mimic ECM properties and promote tissue regeneration are discussed. Finally, we emphasizes the importance of integrating mechanical, biochemical, and metabolic cues in scaffold design for successful tissue engineering applications.